Hoth Therapeutics Announces HT-ALZ Therapeutic Shows Cognitive Improvements in Alzheimer’s Disease Mouse Model
Hoth Therapeutics, Inc. today announced proof-of-concept data generated using cognitive and behavioral assessments in an Alzheimer’s disease mouse model (aged APP/PS1+/- mice), supporting the therapeutic cognitive potential of HT-ALZ after chronic oral dosing. The research was conducted as part of the company’s Sponsored Research Agreement with Washington University in St. Louis. HT-ALZ is therapeutic in development under the 505(b)(2) regulatory pathway for the treatment of dementia-related to Alzheimer’s disease (AD).
The chronic dosing experiments, conducted by Carla Yuede, PhD, Associate Professor of Psychiatry, and John Cirrito, PhD, Associate Professor of Neurology, at Washington University School of Medicine, included a battery of behavioral assessments (eg, pre-pulse inhibition, novel object recognition, cued and contextual fear conditioning) after >5 weeks oral treatment with HT-ALZ. These behavioral assessments are considered the gold standard for predictive cognitive, learning, and memory improvement potential for AD therapeutics. All of the behavioral tests performed after >5 weeks treatment showed a significant improvement in the HT-ALZ treated groups compared to the vehicle treated groups, with similar cognitive and behavioral trends in the HT-ALZ-treated groups compared to the wild type (non-AD) animals. Overall, the results support the therapeutic potential of HT-ALZ to provide cognitive improvement as an AD therapeutic.